Mechanism of phospho-ubiquitin induced PARKIN activation

  title={Mechanism of phospho-ubiquitin induced PARKIN activation},
  author={Tobias Wauer and Michal Sim{\'i}{\vc}ek and Alexander Schubert and David Komander},
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy. PINK1 is stabilized on the outside of depolarized mitochondria and phosphorylates polyubiquitin as well as the PARKIN ubiquitin-like (Ubl) domain. These phosphorylation events lead to PARKIN recruitment to mitochondria, and activation by an unknown allosteric… CONTINUE READING
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