Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells.

@article{Tang2002MechanismOO,
  title={Mechanism of oxidative stress-induced GADD153 gene expression in vascular smooth muscle cells.},
  author={Jia-rong Tang and Michitsugu Nakamura and Takafumi Okura and Yasunori Takata and Sanae Watanabe and Zhao-hui Yang and Jun Yong Liu and Yutaka Kitami and K. Hiwada},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={290 4},
  pages={1255-9}
}
Oxidative stress plays a critical role in normal functioning of cardiac and vascular cells as well as in the pathogenesis of cardiovascular disease. Growth arrest and DNA damage-inducible gene 153 (GADD153), which is upregulated by oxidative stress, regulates the cell cycle and apoptosis. Previously an AP-1 was reported to contribute significantly to GADD153 gene transcriptional activation by oxidative stress. Recently, we have reported that GADD153 gene promoter activity is negatively… CONTINUE READING
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