Corpus ID: 12254434

Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.

  title={Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.},
  author={Yusuke Hiraku and Shosuke Kawanishi},
  journal={Cancer research},
  volume={56 8},
Delta-Aminolevulinic acid (ALA) is a heme precursor accumulated in lead poisoning and acute intermittent porphyria. ALA-induced DNA damage in the presence of metal ions was investigated with a DNA sequencing technique and a high-performance liquid chromatograph equipped with an electrochemical detector. ALA caused damage to DNA fragments obtained from c-Ha-ras proto-oncogene in the presence of Cu(II), but only slightly in the presence of Fe(II). ALA + Cu(II) induced piperidine-labile sites at… Expand
N-acetyl-L-cysteine protects against delta-aminolevulinic acid-induced 8-hydroxydeoxyguanosine formation.
Results showed that levels of ALA up to 5 mM do not inhibit cell proliferation, which suggests a protective role for NAC and the antioxidant enzymes. Expand
Mechanism of oxidative DNA damage induction in a strict anaerobe, Prevotella melaninogenica.
Results indicate that in P. melaninogenica, exposure to O( 2) generated and accumulated O(2)* and H(2)O(2), and that a crypto-OH radical generated through H(4-pyridyl-1-oxide)-N-tert-butylnitrone and ethanol was the active species in the 8OHdG induction. Expand
Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity.
  • L. Patrick
  • Medicine, Chemistry
  • Alternative medicine review : a journal of clinical therapeutic
  • 2006
Antioxidants - vitamins B6, C and E, zinc, taurine, N-acetylcysteine, and alpha-lipoic acid - have been studied in lead-exposed animals and the evidence for their use in lead exposure, alone and in conjunction with chelating agents, is reviewed. Expand
Modulation of lead biohazards using a combination of epicatechin and lycopene in rats
The combined treatment (epicatechin + lycopene) exert its effects (100%) against toxic effects against lead by lowering the liver enzymes alanine transaminase (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP) and gamma glutamyle transferase (GGT) activities and decrease lipid peroixdation (MDA) and enhances the superoxide dismutase (SOD) activity. Expand
Protective effects of ginger (Zingiber officinale Roscoe) against cadmium chloride-induced oxidative stress in the blood of rats
Cadmium is a heavy metal of wide occupational and environmental contamination. In recent years, however, cadmium has been implicated in the pathogenesis of several clinical disorders. Generation ofExpand
Alterations of heme metabolism in lymphocytes and metal content in blood plasma as markers of diesel fuels effects on human organism
Workers in the diesel fuel distribution trade are intensively exposed to fuel vapours. Diesel fuel presents the main source of air pollution by benzene at a marine diesel fuel terminal. Levels ofExpand
Photodynamic Therapy of Activated and Resting Lymphocytes and Its Antioxidant Adaptive Response
Only activated cells are capable of developing an antioxidant adaptive response to PDT treatment, and this response was not further increased when higher amounts of porphyrins were synthesised. Expand
Antioxidant effects of curcumin against cadmium chloride-induced oxidative stress in the blood of rats
Humans are exposed to a number of toxic elements in the environment. Cadmium, widely used in industry, is a great environmental health problem of both humans and animals. Effects of reactive oxygenExpand
Role of wormwood (Artemisia absinthium) extract on oxidative stress in ameliorating lead induced haematotoxicity.
It is suggested that wormwood (Artemisia absinthium) extract restored the enzymes activities perturbed by exposure to lead, and had a protective role against lipid peroxidation. Expand
Antioxidant effects of ginger (Zingiber officinale Roscoe) against lead acetate-induced hepatotoxicity in rats
The results of multi-component spectrophotometric analysis suggest that ginger treatment of lead exposed rats lowered the levels of inactive hemoglobins and elevated the level of active HbO2. Expand