Corpus ID: 12254434

Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.

@article{Hiraku1996MechanismOO,
  title={Mechanism of oxidative DNA damage induced by delta-aminolevulinic acid in the presence of copper ion.},
  author={Yusuke Hiraku and Shosuke Kawanishi},
  journal={Cancer research},
  year={1996},
  volume={56 8},
  pages={
          1786-93
        }
}
Delta-Aminolevulinic acid (ALA) is a heme precursor accumulated in lead poisoning and acute intermittent porphyria. ALA-induced DNA damage in the presence of metal ions was investigated with a DNA sequencing technique and a high-performance liquid chromatograph equipped with an electrochemical detector. ALA caused damage to DNA fragments obtained from c-Ha-ras proto-oncogene in the presence of Cu(II), but only slightly in the presence of Fe(II). ALA + Cu(II) induced piperidine-labile sites at… Expand
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