Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper

  title={Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper},
  author={Shinji Oikawa and Emiko Nagao and Katsuhisa Sakano and Shosuke Kawanishi},
  journal={Free Radical Research},
  pages={966 - 973}
Although capsaicin exhibits antitumor activity, carcinogenic potential has also been reported. To clarify the mechanism for expression of potential carcinogenicity of capsaicin, we examined DNA damage induced by capsaicin in the presence of metal ion and various kinds of cytochrome P450 (CYP) using 32P-5′-end-labeled DNA fragments. Capsaicin induced Cu(II)-mediated DNA damage efficiently in the presence of CYP1A2 and partially in the presence of 2D6. CYP1A2-treated capsaicin caused double-base… 

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