Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.

@article{Meunier2004MechanismOO,
  title={Mechanism of oxidation reactions catalyzed by cytochrome p450 enzymes.},
  author={B. Meunier and S. D. de Visser and S. Shaik},
  journal={Chemical reviews},
  year={2004},
  volume={104 9},
  pages={
          3947-80
        }
}
ion phase that leads to an alkyl radical coordinated to the iron-hydroxo complex by a weak OH---C hydrogen bond, labeled as CI; (ii) an alkyl (or OH) rotation phase whereby the alkyl group achieves a favorable orientation for rebound; and (iii) a rebound phase that leads to C-O bond making and the ferric-alcohol complexes, 4,2P. The two profiles remain close in energy throughout the first two phases and then bifurcate. Whereas the HS state exhibits a significant barrier and a genuine TS for… Expand
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Mechanism of S-oxygenation by a cysteine dioxygenase model complex.
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