Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).

  title={Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).},
  author={Witold Korytowski and Christopher C Felix and Balaraman Kalyanaraman},
  journal={Biochemical and biophysical research communications},
  volume={144 2},
Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings. 

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