Mechanism of odorant adaptation in the olfactory receptor cell

@article{Kurahashi1997MechanismOO,
  title={Mechanism of odorant adaptation in the olfactory receptor cell},
  author={Takashi Kurahashi and Anna Menini},
  journal={Nature},
  year={1997},
  volume={385},
  pages={725-729}
}
Abstract Adaptation to odorants begins at the level of sensory receptor cells1–5, presumably through modulation of their transduction machinery. The olfactory signal transduction involves the activation of the adenylyl cyclase/cyclic AMP second messenger system which leads to the sequential opening of cAMP-gated channels and Ca2+ -activated chloride ion channels4–7. Several reports of results obtained from in vitro preparations describe the possible molecular mechanisms involved in odorant… CONTINUE READING
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