Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist.

@article{Thelen1988MechanismON,
  title={Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist.},
  author={Manfred Thelen and Paola Peveri and P. Kernen and Vinzenz von Tscharner and Alfred Walz and Marco Baggiolini},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1988},
  volume={2 11},
  pages={
          2702-6
        }
}
The rise in cytosolic free Ca2+, shape change, superoxide formation, and granule exocytosis induced in human neutrophils by N-formyl-Met-Leu-Phe (fMLP) and by a newly discovered activating peptide, neutrophil-activating factor, termed NAF, were compared. NAF was effective in the concentration range of 0.1-10 nM and was 10- to 100-fold more potent than fMLP. In qualitative terms, the single responses to either stimulus were remarkably similar: they showed virtually identical onset and initial… CONTINUE READING

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