Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy.

@article{Lacourciere2000MechanismON,
  title={Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy.},
  author={Karen Lacourciere and James T Stivers and John P. Marino},
  journal={Biochemistry},
  year={2000},
  volume={39 19},
  pages={
          5630-41
        }
}
Rev is an essential HIV-1 regulatory protein that binds the Rev responsive element (RRE) within the env gene of the HIV-1 RNA genome and is involved in transport of unspliced or partially spliced viral mRNA from the cell nucleus to the cytoplasm. Previous studies have shown that a short alpha-helical peptide derived from Rev (Rev 34-50), and a truncated form of the RRE sequence provide a useful in vitro system to study this interaction while still preserving the essential aspects of the native… CONTINUE READING
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Molecular Basis of Antibiotic Action

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