Mechanism of muscle glycogen autoregulation in humans.

  title={Mechanism of muscle glycogen autoregulation in humans.},
  author={Didier Laurent and Ripudaman S Hundal and Alex Dresner and Thomas B. Price and Stephen M. Vogel and Kitt Falk Petersen and Gerald I Shulman},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={278 4},
To examine the mechanism by which muscle glycogen limits its own synthesis, muscle glycogen and glucose 6-phosphate (G-6-P) concentrations were measured in seven healthy volunteers during a euglycemic ( approximately 5.5 mM)-hyperinsulinemic ( approximately 450 pM) clamp using (13)C/(31)P nuclear magnetic resonance spectroscopy before and after a muscle glycogen loading protocol. Rates of glycogen synthase (V(syn)) and phosphorylase (V(phos)) flux were estimated during a [1-(13)C]glucose (pulse… CONTINUE READING


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