Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro.

@article{Capogna1993MechanismOM,
  title={Mechanism of mu-opioid receptor-mediated presynaptic inhibition in the rat hippocampus in vitro.},
  author={Marco Capogna and Beat H. G{\"a}hwiler and Scott M. Thompson},
  journal={The Journal of physiology},
  year={1993},
  volume={470},
  pages={539-58}
}
1. The electrophysiological action of the mu-opioid receptor-preferring agonist D-Ala2, MePhe4, Met(O)5-ol-enkephalin (FK 33-824) on synaptic transmission has been studied in area CA3 of organotypic rat hippocampal slice cultures. 2. FK 33-824 (1 microM) had no effect on the amplitude of pharmacologically isolated N-methyl-D-aspartate (NMDA) or non-NMDA receptor-mediated EPSPs. 3. FK 33-824 (10 nM to 10 microM) reduced the amplitude of monosynaptic inhibitory postsynaptic potentials (IPSPs… CONTINUE READING
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