Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine.

@article{Ngan2001MechanismOM,
  title={Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine.},
  author={Vivian K. Ngan and Krista Bellman and Bridget T. Hill and Leslie Wilson and Mary Ann Jordan},
  journal={Molecular pharmacology},
  year={2001},
  volume={60 1},
  pages={225-32}
}
The two second-generation Vinca alkaloids, vinorelbine and vinflunine, affect microtubule dynamics very differently from vinblastine, a first generation Vinca alkaloid. For example, vinblastine strongly suppresses the rate and extent of microtubule shortening in vitro, whereas vinorelbine and vinflunine suppress the rate and extent of microtubule growing events. We asked whether these differences result in differences in mitotic spindle organization that might be responsible for the superior… CONTINUE READING