Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.

@article{Mar2008MechanismOM,
  title={Mechanism of mitochondrial glutathione-dependent hepatocellular susceptibility to TNF despite NF-kappaB activation.},
  author={Montserrat Mar{\'i} and Anna Colell and Albert Morales and Francisco Caballero and Anna Moles and Ana Fern{\'a}ndez and Oihana Terrones and Gorka Bas{\'a}{\~n}ez and Bruno Antonsson and Carmen Garcia-Ruiz and Jos{\'e} C Fern{\'a}ndez-Checa},
  journal={Gastroenterology},
  year={2008},
  volume={134 5},
  pages={1507-20}
}
BACKGROUND & AIMS Nuclear factor kappaB (NF-kappaB) is the master regulator of tumor necrosis factor (TNF) susceptibility. Although mitochondrial glutathione (mGSH) depletion was shown to sensitize hepatocytes to TNF despite NF-kappaB activation, the mechanisms involved, particularly the role of Bax oligomerization and mitochondrial outer membrane (MOM) permeabilization, 2 critical steps in cell death, remained unexplored. METHODS TNF signaling at the premitochondrial and mitochondrial levels… CONTINUE READING

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References

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Showing 1-10 of 52 references

Critical role of acidic sphingomyelinase in murine hepatic ischemia - reperfusion injury

  • JC Fernandez-Checa, N Kaplowitz
  • Hepatology
  • 2006

death by inducing c - FLIP ( L ) turnover

  • ZL Chu, TA McKinsey, L Liu
  • 2006

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