Mechanism of mesaconitine-induced contractile response in guinea pig vas deferens.


Mesaconitine (MA) caused contraction of the isolate guinea pig vas deferens in a dose-dependent manner (3 x 10(-6) - 10-(-4) g/ml) and nonspecifically potentiated the contractile response to norepinephrine (NE), acetylcholine, histamine and tyramine. Tachyphylaxis developed during the repeated application of MA. The contraction produced by MA was prevented… (More)


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