Mechanism of membrane permeabilization by a bacterial trehalose lipid biosurfactant produced by Rhodococcus sp.

@article{Zaragoza2009MechanismOM,
  title={Mechanism of membrane permeabilization by a bacterial trehalose lipid biosurfactant produced by Rhodococcus sp.},
  author={Ana Zaragoza and Francisco Jos{\'e} Aranda and Mar{\'i}a Jos{\'e} Espuny and Jos{\'e} Antonio Teruel and Ana Evangelista Marques and {\'A}ngeles Manresa and Antonio Ort{\'i}z},
  journal={Langmuir : the ACS journal of surfaces and colloids},
  year={2009},
  volume={25 14},
  pages={7892-8}
}
The interactions of a succinoyl bacterial trehalose lipid biosurfactant produced by Rhodococcus sp. with phospholipid vesicles, leading to membrane permeabilization, are studied by means of calorimetric and fluorescence and absorption spectroscopical techniques in search for a molecular model. The critical micelle concentration (CMC) of trehalose lipid is determined, by surface tension measurements, to be 300 muM. Binding of trehalose lipid to palmitoyloleoylphosphatidylcholine membranes is… CONTINUE READING

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