Mechanism of liver-selective thyromimetic activity of SK&F L-94901: evidence for the presence of a cell-type-specific nuclear iodothyronine transport process.

@article{Ichikawa2000MechanismOL,
  title={Mechanism of liver-selective thyromimetic activity of SK&F L-94901: evidence for the presence of a cell-type-specific nuclear iodothyronine transport process.},
  author={Kazuo Ichikawa and Takahide Miyamoto and Tomoko Kakizawa and Satoru Suzuki and Atsushi Kaneko and J i Mori and Mitsunobu Hara and Masayoshi Kumagai and Teiji Takeda and Kiyoshi Hashizume},
  journal={The Journal of endocrinology},
  year={2000},
  volume={165 2},
  pages={391-7}
}
The thyromimetic compound SK&F L-94901 shows more potent thyromimetic activity in the liver than in the pituitary gland or heart when administered to rats. The mechanisms of liver-selectivity of SK&F L-94901 were examined using cultured rat hepatoma cells (dRLH-84) and rat pituitary tumor cells (GH3), both of which showed saturable cellular uptake of tri-iodothyronine (T(3)). When isolated nuclei with partial disruption of the outer nuclear membrane were used, SK&F L-94901 competed for [(125)I… CONTINUE READING

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