Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.

@article{Dasgupta2011MechanismOL,
  title={Mechanism of lipid induced insulin resistance: activated PKCε is a key regulator.},
  author={Suman Dasgupta and Sushmita Bhattacharya and Sudipta Maitra and Durba Pal and Subeer S Majumdar and Asis Datta and Samir Bhattacharya},
  journal={Biochimica et biophysica acta},
  year={2011},
  volume={1812 4},
  pages={495-506}
}
Fatty acids (FAs) are known to impair insulin signaling in target cells. Accumulating evidences suggest that one of the major sites of FAs adverse effect is insulin receptor (IR). However, the underlying mechanism is yet unclear. An important clue was indicated in leptin receptor deficient (db/db) diabetic mice where increased circulatory FAs was coincided with phosphorylated PKCε and reduced IR expression. We report here that central to this mechanism is the phosphorylation of PKCε by FAs… CONTINUE READING