Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11

@article{Shigesada2004MechanismOL,
  title={Mechanism of leukemogenesis by the inv(16) chimeric gene CBFB/PEBP2B-MHY11},
  author={Katsuya Shigesada and Bart van de Sluis and Piu Paul Liu},
  journal={Oncogene},
  year={2004},
  volume={23},
  pages={4297-4307}
}
Inv(16)(p13q22) is associated with acute myeloid leukemia subtype M4Eo that is characterized by the presence of myelomonocytic blasts and atypical eosinophils. This chromosomal rearrangement results in the fusion of CBFB and MYH11 genes. CBFβ normally interacts with RUNX1 to form a transcriptionally active nuclear complex. The MYH11 gene encodes the smooth muscle myosin heavy chain. The CBFβ-SMMHC fusion protein is capable of binding to RUNX1 and form dimers and multimers through its myosin… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 13 references

Blood Cells Mol

  • K Inoue, S Ozaki, +8 authors Y. Ito
  • Dis., 30, 157–160.
  • 2003
1 Excerpt

Dev

  • ML Kalev-Zylinska, JA Horsfield, +6 authors KE. Crosier
  • Dyn., 228, 323–336.
  • 2003
1 Excerpt

Cell Signal, 12, 317–326

  • MD.
  • Durst KL, Lutterbach B, Kummalue T, Friedman AD…
  • 2000

Nat

  • DA Yergeau, CJ Hetherington, +7 authors DE. Zhang
  • Genet., 15, 303–306.
  • 1997

Oncogene, 15, 1315–1327

  • PP Liu, Friedman AD.
  • Care RS, Valk PJ, Goodeve AC, Abu-Duhier FM…
  • 1997

Cell, 87, 687–696

  • Liu PP.
  • Chung CH, Bernard PS and Perou CM. (2002). Nat…
  • 1996

Genes Chromosomes Cancer , 16 , 77 – 87 . Look AT . ( 1997 )

  • PP Liu, C Wijmenga, +8 authors FS Collins
  • Science
  • 1996
1 Excerpt

J

  • JQ Xu, BA Harder, P Uman, R. Craig
  • Cell Biol., 134, 53–66.
  • 1996

Proc

  • C Wijmenga, PE Gregory, +5 authors FS. Collins
  • Natl. Acad. Sci. U.S.A., 93, 1630–1635.
  • 1996

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