Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells.

  title={Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells.},
  author={Jan Henryk Spodnik and Michal Woźniak and Dorota Budzko and Masa-aki Teranishi and Mariusz Karbowski and Yuji Nishizawa and Jiro Usukura and Takashi Wakabayashi},
  volume={2 3},
Leflunomide (LFM) is an inhibitor of mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) that catalyzes the conversion of dihydroorotate to orotate coupled with the generation of reactive oxygen species (ROS) from mitochondria. We demonstrate here that LFM causes an unrestrained proliferation of mitochondria both in human osteosarcoma cell line 143B cells and rat liver derived RL-34 cells. Increases in the total mass of mitochondria per cell in LFM-treated cells were evidenced by the… CONTINUE READING

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