Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats.

@article{Gu2008MechanismOI,
  title={Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats.},
  author={Guojun Gu and Yun-ping Li and Zhang Peng and Jia-jun Xu and Zhi-min Kang and Weigang Xu and Heng-yi Tao and Robert P. Ostrowski and John H. Zhang and Xue-jun Sun},
  journal={Journal of applied physiology},
  year={2008},
  volume={104 4},
  pages={
          1185-91
        }
}
We studied the effect of hyperbaric oxygen (HBO) preconditioning on the molecular mechanisms of neuroprotection in a rat focal cerebral ischemic model. Seventy-two male Sprague-Dawley rats were pretreated with HBO (100% O(2), 2 atmospheres absolute, 1 h once every other day for 5 sessions) or with room air. In experiment 1, HBO-preconditioned rats and matched room air controls were subjected to focal cerebral ischemia or sham surgery. Postinjury motor parameters and infarction volumes of HBO… 

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  • 2013
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...

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