Mechanism of irritant-induced cough: Studies with a kinin antagonist and a kallikrein inhibitor

@article{Featherstone1996MechanismOI,
  title={Mechanism of irritant-induced cough: Studies with a kinin antagonist and a kallikrein inhibitor},
  author={Roland Lewis Featherstone and john. parry and David M. Evans and Dylan M. Jones and H{\aa}kan Olsson and Michael Szelke and M K Church},
  journal={Lung},
  year={1996},
  volume={174},
  pages={269-275}
}
It has been suggested that bradykinin may play a role in stimulating cough in at least one pathological condition in humans. We have employed an animal model to investigate the possible role of this peptide in irritant-induced cough. The kinin antagonist Hoe 140 and codeine both produced dose-related inhibition of cough responses to inhalation of citric acid or bradykinin aerosols by conscious guinea pigs. The selective tissue kallikrein inhibitor CH694 inhibited cough caused by citric acid but… CONTINUE READING