Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.

  title={Mechanism of interleukin-25 (IL-17E)-induced pulmonary inflammation and airways hyper-reactivity.},
  author={T Sharkhuu and Klaus Ingo Matthaei and Elizabeth Forbes and Suresh Mahalingam and Simon P Hogan and Philip M Hansbro and Paul S Foster},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  volume={36 12},
BACKGROUND IL-25, a novel member of the IL-17 cytokine family, promotes CD4+ T-helper 2 lymphocyte-like (Th type-2) inflammatory responses in the lung. Although IL-25 up-regulates IL-13 in the lung, the contribution of this and other type 2 cytokine signalling pathways to the induction and persistence of airways hyper-reactivity (AHR) and allergic inflammation are unclear. OBJECTIVE To determine the downstream factors employed by IL-25 to induce Th type-2 pulmonary inflammation and AHR… CONTINUE READING
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