Mechanism of interferon action: in vivo activation of 91 kDa transcription factor.

Interferons are a family of secreted polypeptides with distinct biological effects. These effects include the regulation of expression of specific cellular genes, antiviral properties, and inhibition of cell growth and proliferation. We investigated the effect of sodium orthovanadate (vanadate), an inhibitor of protein-phosphotyrosine phosphatases, on early… CONTINUE READING