Mechanism of interaction of digitalis with estradiol binding sites in rat uteri.

@article{Rifka1976MechanismOI,
  title={Mechanism of interaction of digitalis with estradiol binding sites in rat uteri.},
  author={S M Rifka and J. R. Castrej{\'o}n Pita and Donald L Loriaux},
  journal={Endocrinology},
  year={1976},
  volume={99 4},
  pages={1091-6}
}
Digitalis preparations have a weak estrogenic effect in man. The data in animals are equivocal. We have studied.the biologic effect of both digitoxin and digoxin on the rat uterus in vivo and the interaction of these drugs with the rat uterus estrogen receptor in vitro. Digitoxin and estradiol significantly increased the uterine weight of immature rats, while digoxin did not. The interaction of digitoxin and digoxin with the rat uterus estrogen cytosol receptor was studied using protamine… CONTINUE READING

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