Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis.


Receptor binding studies show that resistance of a laboratory-selected Plodia interpunctella strain to a Bacillus thuringiensis insecticidal crystal protein (ICP) is correlated with a 50-fold reduction in affinity of the membrane receptor for this protein. The strain is sensitive to a second type of ICP that apparently recognizes a different receptor. Understanding the mechanism of resistance will provide strategies to prevent or delay resistance and hence prolong the usefulness of B. thuringiensis ICPs as environmentally safe insecticides.

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@article{Rie1990MechanismOI, title={Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis.}, author={Jeroen Van Rie and W H Mcgaughey and Donovan E. Johnson and Brian D Barnett and H Van Mellaert}, journal={Science}, year={1990}, volume={247 4938}, pages={72-4} }