Mechanism of inhibition of protein synthesis by macrolide and lincosamide antibiotics.

During protein synthesis on the ribosome, the growing peptide is linked covalently to a transfer RNA. With a certain probability this peptidyl-tRNA dissociates from the ribosome, whereupon it becomes susceptible to hydrolysis catalyzed by peptidyl-tRNA hydrolase. When placed at nonpermissive temperatures, mutant (pthts) Escherichia coli that are temperature… CONTINUE READING