Mechanism of inhibition of matrix metalloproteinase-9 induction by NO in vascular smooth muscle cells.

@article{Gurjar2001MechanismOI,
  title={Mechanism of inhibition of matrix metalloproteinase-9 induction by NO in vascular smooth muscle cells.},
  author={Milind V Gurjar and Jason Deleon and Ram V. Sharma and Ramesh C Bhalla},
  journal={Journal of applied physiology},
  year={2001},
  volume={91 3},
  pages={
          1380-6
        }
}
Vascular smooth muscle (VSM) cell migration is a critical step in the development of a neointima after angioplasty. Matrix metalloproteinases (MMPs) degrade the basement membrane and extracellular matrix, facilitating VSM cell migration. Recently, we demonstrated that nitric oxide (NO) inhibits interleukin-1 beta (IL-1 beta)-stimulated MMP-9 induction in rat aortic VSM cells. In this study, we examined the hypothesis that NO inhibits MMP-9 induction by attenuating superoxide generation and… CONTINUE READING