Mechanism of inhibition of Bacillus subtilis DNA polymerase 3 by the arylhydrazinopyrimidine antimicrobial agents.

Abstract

Arylhydrazinopyrimidines inhibit DNA synthesis in Bacillus subtilis by promoting formation of a specific, long-lived ternary complex with DNA polymerase III and the template-primer DNA. DNA polymerase III contains an associated, single-strand-selective exonuclease which generates 5'-mononucleotides. Drug inhibition of the nuclease similarly proceeds through… (More)

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@article{Low1974MechanismOI, title={Mechanism of inhibition of Bacillus subtilis DNA polymerase 3 by the arylhydrazinopyrimidine antimicrobial agents.}, author={Ryan Low and S A Rashbaum and N. R. Cozzarelli}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1974}, volume={71 8}, pages={2973-7} }