Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats.

@article{Dong1988MechanismOI,
  title={Mechanism of induction of cytochrome P-450ac (P-450j) in chemically induced and spontaneously diabetic rats.},
  author={Zhen-nan Dong and Jungil Hong and Qingsheng Ma and Dong-mei Li and J. C. Bullock and Frank J. Gonzalez and S. S. Park and H. V. Gelboin and Chung S Yang},
  journal={Archives of biochemistry and biophysics},
  year={1988},
  volume={263 1},
  pages={
          29-35
        }
}
Previous studies demonstrated that a microsomal high-affinity N-nitrosodimethylamine demethylase activity and cytochrome P-450ac (an acetone/ethanol-inducible form) were induced by streptozotocin-induced diabetes in rats. In the present work, the induction was studied in detail in two chemically induced (by streptozotocin and alloxan) diabetic rat models and one spontaneously (BB/Wor) diabetic rat model. All the diabetic conditions caused increases in three parameters: (a) microsomal N… CONTINUE READING
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