Mechanism of inactivation of thyroid peroxidase by thioureylene drugs.

  title={Mechanism of inactivation of thyroid peroxidase by thioureylene drugs.},
  author={Harald Engler and A Taurog and Toshiaki Nakashima},
  journal={Biochemical pharmacology},
  volume={31 23},
We have investigated the mechanism by which the thioureylene drugs, 1-methyl-2-mercaptoimidazole (MMI) and 6-n-propylthiouracil (PTU), inactivate thyroid peroxidase (TPO). Our results indicate that inactivation of TPO by MMI and PTU involves a reaction between the drugs and the oxidized heme group produced by interaction between TPO and H2O2. This conclusion is supported by the following observations. First, addition of a low concentration of H2O2 to a solution of TPO shifted lambda max of the… CONTINUE READING

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