Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.

@article{Cline1997MechanismOI,
  title={Mechanism of impaired insulin-stimulated muscle glucose metabolism in subjects with insulin-dependent diabetes mellitus.},
  author={Gary W. Cline and I Magnusson and Douglas L. Rothman and Kitt Falk Petersen and Didier Laurent and Gerald I Shulman},
  journal={The Journal of clinical investigation},
  year={1997},
  volume={99 9},
  pages={2219-24}
}
To determine the mechanism of impaired insulin-stimulated muscle glycogen metabolism in patients with poorly controlled insulin-dependent diabetes mellitus (IDDM), we used 13C-NMR spectroscopy to monitor the peak intensity of the C1 resonance of the glucosyl units in muscle glycogen during a 6-h hyperglycemic-hyperinsulinemic clamp using [1-(13)C]glucose-enriched infusate followed by nonenriched glucose. Under similar steady state (t = 3-6 h) plasma glucose (approximately 9.0 mM) and insulin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 16 references

Overexpression of glutamine: fructose-6-phosphate in skeletal muscle of transgenic mice results in insulin resistance

  • L. F. Herber, D. A. McClain
  • Diabetes. 44:15A. Downloaded from http://www.jci…
  • 1995
1 Excerpt

Validation of 13C NMR measurement of human muscle glycogen by comparison with biopsy and direct biochemical measurement

  • R. Taylor, T. B. Price, D. L. Rothman, R. G. Shulman, G. I. Shulman
  • Magn. Reson. Med
  • 1992
1 Excerpt

Discovery of a meta Downloaded from http://www.jci.org on October

  • S. Marshall, V. Bacate, R.R
  • Traxinger
  • 1991
1 Excerpt

Similar Papers

Loading similar papers…