Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive rats: role of 20-HETE.

@article{Ren2014MechanismOI,
  title={Mechanism of impaired afferent arteriole myogenic response in Dahl salt-sensitive rats: role of 20-HETE.},
  author={Yilin Ren and Martin A D'Ambrosio and Jeffrey L. Garvin and Edward L. Peterson and Oscar A. Carretero},
  journal={American journal of physiology. Renal physiology},
  year={2014},
  volume={307 5},
  pages={F533-8}
}
The afferent arteriole (Af-Art) controls glomerular capillary pressure, an important determinant of glomerular injury. Af-Art myogenic response is mediated by ATP, and ATP signaling is in turn mediated by 20-HETE. Dahl salt-sensitive rats (Dahl SS) have decreased renal 20-HETE production. We hypothesized that Dahl SS have an impaired myogenic response and constrictor response to ATP, due to decreased 20-HETE. Af-Arts from Dahl SS or Dahl salt-resistant rats (Dahl SR) were microdissected and… CONTINUE READING
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Dahl Memorial Lecture

  • K. Inscho EW. Lewis
  • Mysteries of renal autoregulation. Hypertension
  • 2009
Highly Influential
6 Excerpts

necting tubule glomerular feedback in

  • JM Williams, F Fan, +4 authors RJ Roman
  • HYPERTENSION
  • 2013

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