Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells.

@article{Gabrilovich2001MechanismOI,
  title={Mechanism of immune dysfunction in cancer mediated by immature Gr-1+ myeloid cells.},
  author={Dmitry I Gabrilovich and Markwin P. Velders and Eduardo M. Sotomayor and Wijbe Martin Kast},
  journal={Journal of immunology},
  year={2001},
  volume={166 9},
  pages={5398-406}
}
The mechanism of tumor-associated T cell dysfunction remains an unresolved problem of tumor immunology. Development of T cell defects in tumor-bearing hosts are often associated with increased production of immature myeloid cells. In tumor-bearing mice, these immature myeloid cells are represented by a population of Gr-1(+) cells. In this study we investigated an effect of these cells on T cell function. Gr-1(+) cells were isolated from MethA sarcoma or C3 tumor-bearing mice using cell sorting… CONTINUE READING
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