Mechanism of hypotension following rapid infusion of protamine sulfate in anesthetized dogs.

@article{Kien1992MechanismOH,
  title={Mechanism of hypotension following rapid infusion of protamine sulfate in anesthetized dogs.},
  author={Nguyen Duc Kien and D D Quam and John A. Reitan and David A. White},
  journal={Journal of cardiothoracic and vascular anesthesia},
  year={1992},
  volume={6 2},
  pages={143-7}
}
Protamine sulfate (PS), used to neutralize the anticoagulant effect of heparin, is often associated with systemic hypotension. Whether this hypotension is secondary to a depression of myocardial function is not clear. The present study tested the hypothesis that systemic hypotension was accompanied by a depression in myocardial function and examined the possible role of histamine in mediating the cardiovascular response to PS. Seven conditioned dogs were chronically instrumented with pressure… CONTINUE READING