Mechanism of hydroxylamine inhibition of xanthosine 5'-phosphate aminase.

T. Fukuyama; K. L. Donovan

DOI:10.1016/s0021-9258(18)91934-4

Corpus ID: 34994722

Mechanism of hydroxylamine inhibition of xanthosine 5'-phosphate aminase.

@article{Fukuyama1968MechanismOH,
  title={Mechanism of hydroxylamine inhibition of xanthosine 5'-phosphate aminase.},
  author={T. Fukuyama and K. L. Donovan},
  journal={The Journal of biological chemistry},
  year={1968},
  volume={243 21},
  pages={
          5798-801
        }
}

T. Fukuyama, K. L. Donovan
Published 1968
Medicine, Chemistry
The Journal of biological chemistry

Abstract The reaction of xanthosine 5'-phosphate aminase (xanthosine-5'-phosphate:ammonia ligase (AMP), EC 6.3.4.1) with hydroxylamine, xanthosine 5'-phosphate, and adenosine triphosphate results in the formation of 1 mole each of adenosine 5'-phosphate and a derivative of XMP, presumably 2-hydroxylamino-IMP, per mole of aminase. The derivative is enzyme-bound, but can be released by extraction with trichloracetic acid. The compound is a powerful inhibitor of the aminase. These observations… Expand

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