Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment.

@article{Wu2009MechanismOH,
  title={Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment.},
  author={Xue-ling Wu and Tongqing Zhou and Sijy O'dell and Richard T. Wyatt and Peter D. Kwong and John R. Mascola},
  journal={Journal of virology},
  year={2009},
  volume={83 21},
  pages={10892-907}
}
The region of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 that engages its primary cellular receptor CD4 forms a site of vulnerability to neutralizing antibodies. The monoclonal antibody b12 exploits the conservation and accessibility of the CD4-binding site to neutralize many, though not all, HIV-1 isolates. To understand the basis of viral resistance to b12, we used the atomic-level definition of b12-gp120 contact sites to study a panel of diverse circulating… CONTINUE READING