Mechanism of homophilic cadherin adhesion.

  title={Mechanism of homophilic cadherin adhesion.},
  author={Deborah E. Leckband and Sanjeevi Sivasankar},
  journal={Current opinion in cell biology},
  volume={12 5},
Direct measurements of the distance-dependent forces between membrane-bound cadherins were used to test current models of homophilic cadherin interactions. The results reveal a complex binding mechanism in which the proteins adhere in multiple alignments that involve more than the amino-terminal domains.