Mechanism of hepatocellular dysfunction during hyperdynamic sepsis.

  title={Mechanism of hepatocellular dysfunction during hyperdynamic sepsis.},
  author={Ping Wang and Irshad H. Chaudry},
  journal={The American journal of physiology},
  volume={270 5 Pt 2},
Because of its central role in metabolism and host defense mechanisms, the liver is thought to be a major organ responsible for the initiation of multiple organ failure during sepsis. It is, therefore, important to discuss whether hepatocellular dysfunction occurs during early sepsis and, if so, whether this occurs prior to hepatocellular damage as evidenced by elevation in serum enzyme levels. Because indocyanine green clearance has been demonstrated to be an early and extremely sensitive… CONTINUE READING
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