Mechanism of hepatocellular dysfunction during early sepsis. Key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6.

@article{Wang1997MechanismOH,
  title={Mechanism of hepatocellular dysfunction during early sepsis. Key role of increased gene expression and release of proinflammatory cytokines tumor necrosis factor and interleukin-6.},
  author={Ping Wang and Zheng F. Ba and Irshad H. Chaudry},
  journal={Archives of surgery},
  year={1997},
  volume={132 4},
  pages={364-9; discussion 369-70}
}
BACKGROUND Hepatocellular dysfunction occurs at 1.5 hours after cecal ligation and puncture (CLP [ie, sepsis model]), despite normal cardiac output and hepatic perfusion. OBJECTIVE To determine whether proinflammatory cytokines such as tumor necrosis factor (TNF) and interleukin-6 (IL-6) are up-regulated before the occurrence of hepatocellular dysfunction during sepsis. DESIGN, INTERVENTION, AND MAIN OUTCOME MEASURE: Rats were subjected to sepsis by CLP, followed by administration of normal… CONTINUE READING

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