Corpus ID: 42691755

Mechanism of hepatic assimilation of dipeptides. Transport versus hydrolysis.

@article{Lochs1986MechanismOH,
  title={Mechanism of hepatic assimilation of dipeptides. Transport versus hydrolysis.},
  author={H. G. M. Lochs and Emile L. Morse and Siamak A. Adibi},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 32},
  pages={
          14976-81
        }
}
  • H. G. M. Lochs, Emile L. Morse, Siamak A. Adibi
  • Published 1986
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • To investigate dipeptide assimilation by the liver, a series of interrelated experiments were performed in rats. Partial hepatectomy prolonged the plasma half-life (min) of Gly-Ala (3.42 +/- 0.22 versus 4.90 +/- 0.35, p less than 0.05) but had no significant effect on plasma half-life of Gly-Leu, Gly-Pro, or Gly-Sar. We then investigated the rate of disappearance (mumol X (g liver X h)-1) of the above four dipeptides (initial concentration = 1 mM) from the medium during isolated liver perfusion… CONTINUE READING

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    Study of the interaction between a novel, protein stabilizing dipeptide and Interferon-alpha-2a by construction of a Markov State Model from Molecular Dynamics simulations.

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    Peptides in human nutrition.

    Professor Herbert Lochs

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