Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes.

@article{Kobayashi1990MechanismOG,
  title={Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes.},
  author={Kazuo Kobayashi and Y Sogame and Hideyuki Hara and Kazuhiro Hayashi},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 14},
  pages={7737-41}
}
Transport of S-(2,4-dinitrophenyl)glutathione (DNP-SG), a model compound of glutathione S-conjugates, was studied in purified canalicular and basolateral (i.e. sinusoidal and lateral) rat liver plasma membrane (LPM) vesicles. Incubation of canalicular LPM vesicles with DNP-SG in the presence of ATP resulted in an uptake of DNP-SG into the vesicles. In contrast, in basolateral LPM vesicles the initial rate of ATP-dependent DNP-SG uptake was 3-4-fold lower than that of the canalicular LPM. This… CONTINUE READING

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