Mechanism of glia-neuron cell-fate switch in the Drosophila thoracic neuroblast 6-4 lineage.

@article{AkiyamaOda2000MechanismOG,
  title={Mechanism of glia-neuron cell-fate switch in the Drosophila thoracic neuroblast 6-4 lineage.},
  author={Y. Akiyama-Oda and Yoshiki Hotta and Shoichiro Tsukita and Hiroki Oda},
  journal={Development},
  year={2000},
  volume={127 16},
  pages={3513-22}
}
During development of the Drosophila central nervous system, neuroblast 6-4 in the thoracic segment (NB6-4T) divides asymmetrically into a medially located glial precursor cell and a laterally located neuronal precursor cell. In this study, to understand the molecular basis for this glia-neuron cell-fate decision, we examined the effects of some known mutations on the NB6-4T lineage. First, we found that prospero (pros) mutations led to a loss of expression of Glial cells missing, which is… CONTINUE READING

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