Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.

@article{Miller1992MechanismOG,
  title={Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.},
  author={Christopher J Miller and Nancy J. Alexander and Peter Vogel and James F. Anderson and Preston A Marx},
  journal={Journal of medical primatology},
  year={1992},
  volume={21 2-3},
  pages={64-8}
}
To understand the biologic processes involved in transmission of HIV, we examined the genital tracts of chronically infected female macaques and localized SIV-infected cells. SIV was found in the genital tract of 12 of 16 animals and SIV-infected cells were located in the cervix and vagina. Inoculation of cell-free SIV into the blind vaginal pouch of hysterectomized macaques resulted in systemic infection. We propose a hypothesis to explain the early events in the genital transmission of SIV. 

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