Mechanism of gastrointestinal absorption of glycyrrhizin in rats.

  title={Mechanism of gastrointestinal absorption of glycyrrhizin in rats.},
  author={Zhong Jing Wang and Yuji Kurosaki and Taiji Nakayama and T. D. Kimura},
  journal={Biological & pharmaceutical bulletin},
  volume={17 10},
The mechanism of gastrointestinal absorption of glycyrrhizin (GZ) was examined in rats. Using an in situ loop technique, it was found that the intestinal absorption of glycyrrhetic acid (GA), a major metabolite of GZ, was larger than that of GZ and that the absorption of GA was larger in the small intestine than in the large intestine. Although GZ was poorly absorbable, both GZ and GA were detected in rat plasma after oral administration of GZ, suggesting that GZ can be absorbed in both parent… CONTINUE READING


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