Mechanism of fusion of Sendai virus: role of hydrophobic interactions and mobility constraints of viral membrane proteins. Effects of polyethylene glycol.

@article{Hoekstra1989MechanismOF,
  title={Mechanism of fusion of Sendai virus: role of hydrophobic interactions and mobility constraints of viral membrane proteins. Effects of polyethylene glycol.},
  author={Dick Hoekstra and Karin Klappe and H C Hoff and Shlomo Nir},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 12},
  pages={6786-92}
}
The mechanism of Sendai virus fusion was investigated by studying the effect of the dehydrating agent polyethylene glycol (PEG) on the interaction of the virus with erythrocyte membranes. The initial rate of virus fusion, monitored continuously by a fluorescence membrane fusion assay, increases approximately 5-fold in the presence of small amounts (4%, w/v) of PEG. The polymer did not trigger a massive nonspecific fusion event, as the limited number of virus particles that fuse per erythrocyte… CONTINUE READING
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Mechanisms of Membrane

  • Corp, M. New York Hsu, A. Scheid, P. W. Choppin
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