Mechanism of frequency-dependent broadening of molluscan neurone soma spikes.

@article{Aldrich1979MechanismOF,
  title={Mechanism of frequency-dependent broadening of molluscan neurone soma spikes.},
  author={Richard W. Aldrich and Peter A. Getting and Stuart H. Thompson},
  journal={The Journal of physiology},
  year={1979},
  volume={291},
  pages={531-44}
}
1. Action potentials recorded from isolated dorid neurone somata increase in duration, i.e. broaden, during low frequency repetitive firing. Spike broadening is substantially reduced by external Co ions and implicates an inward Ca current. 2. During repetitive voltage clamp steps at frequencies slower than 1 Hz, in 100 mM-tetraethyl ammonium ions (TEA) inward Ca currents do not increase in amplitude. 3. Repetitive action potentials result in inactivation of delayed outward current. Likewise… CONTINUE READING