Mechanism of free radical-induced hemolysis of human erythrocytes: hemolysis by water-soluble radical initiator.

@article{Sato1995MechanismOF,
  title={Mechanism of free radical-induced hemolysis of human erythrocytes: hemolysis by water-soluble radical initiator.},
  author={Yuji Sato and Satoshi Kamo and Tsutomu Takahashi and Yota Suzuki},
  journal={Biochemistry},
  year={1995},
  volume={34 28},
  pages={8940-9}
}
Hemolysis of human erythrocytes induced by free radicals initiated from water-soluble, 2,2'-azobis(amidinopropane) dihydrochloride (AAPH) has been investigated. The formation of the radical detected as DMPO (5,5-dimethyl-1-pyrroline N-oxide) adduct depended on temperature and AAPH concentration in a similar manner as hemolysis. The curve for the formation of DMPO--radical adduct, however, did not correspond directly to the hemolysis curve. The product of thiobarbituric acid-reactive materials… CONTINUE READING

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