Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops.

@article{Pearson1989MechanismOF,
  title={Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops.},
  author={S. D. Pearson and K. Owen Ash and Francis M. Urry},
  journal={Clinical chemistry},
  year={1989},
  volume={35 4},
  pages={
          636-8
        }
}
To drug-free urine specimens, we added the following drugs of abuse to give concentrations twice the cutoff value for positive test results: 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (9-carboxy-THC), oxazepam, secobarbital, morphine, benzoylecgonine, amphetamine, or phencyclidine (PCP). Visine was then added. Although measured concentrations of several drugs were decreased in the presence of Visine, false-negative results were obtained only for 9-carboxy-THC for the EMIT-d.a.u. and TDx… CONTINUE READING

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