Mechanism of extracellular ubiquitination in the mammalian epididymis.

  title={Mechanism of extracellular ubiquitination in the mammalian epididymis.},
  author={Kathleen M. Baska and Gaurishankar Manandhar and Dawn Feng and Yuksel Agca and Mark W. Tengowski and Miriam Sutovsky and Y. J. Yi and Peter Sutovsky},
  journal={Journal of cellular physiology},
  volume={215 3},
Posttranslational modification by ubiquitination marks defective or outlived intracellular proteins for proteolytic degradation by the 26S proteasome. The ATP-dependent, covalent ligation and formation of polyubiquitin chains on substrate proteins requires the presence and activity of a set of ubiquitin activating and conjugating enzymes. While protein ubiquitination typically occurs in the cell cytosol or nucleus, defective mammalian spermatozoa become ubiquitinated on their surface during… CONTINUE READING
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