Mechanism of extracellular thiol nitrosylation by N(2)O(3) produced by activated macrophages.

@article{Gobert1999MechanismOE,
  title={Mechanism of extracellular thiol nitrosylation by N(2)O(3) produced by activated macrophages.},
  author={Alain P Gobert and Philippe Vincendeau and Djavad Mossalayi and Bernard Veyret},
  journal={Nitric oxide : biology and chemistry},
  year={1999},
  volume={3 6},
  pages={467-72}
}
Reactive nitrogen intermediates are synthesized by activated macrophages. These molecules, and nitrous anhydride (N(2)O(3)) in particular, are known to be potent nitrosylating species. We investigated the role of macrophage-derived N(2)O(3) in extracellular nitrosylation. We used dilution experiments to demonstrate the intracellular production of N(2)O(3) and its export into the extracellular medium, with a rate constant k(ex) = 6.8 x 10(6) M s(-1). The kinetics of the competition between… CONTINUE READING